Many people are affected by the skin condition known as hyperpigmentation. The overproduction of melanin, which causes dark areas on the skin, is what makes it distinctive. Sun exposure, hormone fluctuations, heredity, and other factors can all contribute to hyperpigmentation. Tyrosinase inhibitors are a well-liked and practical alternative among the numerous therapies for hyperpigmentation.

What are Tyrosinase Inhibitors?

Tyrosinase inhibitors are substances that either directly or indirectly prevent the skin's melanin from being produced. They take care of practically all pigmentation issues. The beauty industry uses tyrosinase inhibitors to stop hyperpigmentation, tanning, and other skin problems.

However, tyrosinase activity cannot be suppressed if you were born with dark skin. Only melanin that has been overproduced as a result of environmental factors like UV exposure can be suppressed.

Synthesis of melanin inhibitor is now helped by an enzyme called tyrosinase in skin cells. Tyrosinase inhibition thereby reduces melanin production, which in turn reduces melanin output. Therefore, tyrosinase inhibitors are drugs that stop or delay tyrosinase production, which then reduces the excessive production of melanin, giving you more lighter and even skin tone.

How Tyrosinase Influences Melanin Production?

Tyrosinase is an enzyme that is essential for the process of producing melanin. Tyrosinase converts the amino acid tyrosine into dopaquinone to start the formation of melanin. Melanin, which gives colour to the skin, hair, and eyes, is created when dopaquinone combines with other compounds.

Hyperpigmentation happens when melanin is produced excessively. Tyrosinase affects the formation of melanin by accelerating the conversion of tyrosine into dopaquinone, an essential step in the synthesis of melanin. Tyrosinase activity can be managed to regulate the level of melanin generated.

Increased tyrosinase activity will cause more melanin to be produced, which will result in hyperpigmentation. On the other side, if tyrosinase activity is diminished, less melanin will be produced, which can aid in lessening hyperpigmentation. Tyrosinase inhibitors function by lowering tyrosinase activity, which in turn lowers melanin synthesis and aids in the reduction of hyperpigmentation.

Tyrosinase Inhibitors List: 16 best Tyrosinase Inhibitors that Reduce Hyperpigmentation

Tyrosinase inhibitors are drugs that lessen tyrosinase activity, which in turn lessens melanin synthesis. Tyrosinase inhibitors come in a wide variety, each with a special mode of action. The following are some of the most popular tyrosinase inhibitors:

Aloesin

A tyrosinase inhibitor called aloesin is produced by the aloe vera plant. It is a natural substance that has been discovered to successfully lower the skin's melanin production. According to studies, aloesin can lessen hyperpigmentation by lowering the skin's melanin production. Additionally, it has been discovered to have anti-inflammatory qualities, making it a suitable option for people with sensitive skin.

Arbutin

Plants including bearberry, blueberry, and pears are sources of arbutin. It is a natural and risk-free substitute for hydroquinone, a typical skin-lightening chemical that may cause unfavourable side effects. By lowering melanin production, arbutin has been proven to be useful in reducing hyperpigmentation and evening out skin tone.

Artemisia Capillaris

Artemisia capillaris, sometimes called sweet wormwood or Artemisia annua. It has been discovered to contain artemisinin, a tyrosinase inhibitor that has been demonstrated to lessen the skin's production of melanin. Tyrosinase, an enzyme that catalyses the oxidation of tyrosine, a crucial step in the synthesis of melanin, is what it does its job by blocking.

Ascorbic acid

Ascorbic Acid possess tyrosinase inhibitory qualities. It has been discovered that ascorbic acid, a strong antioxidant, can shield the skin from UV and free radical damage. Additionally, it has been discovered to increase collagen formation, which is crucial for preserving the skin's firmness and suppleness.

Azelaic acid

It has been discovered that the naturally occurring dicarboxylic acid azelaic acid contains tyrosinase-inhibiting effects. Tyrosinase, the enzyme that catalyses the oxidation of tyrosine, a crucial step in the synthesis of melanin, is inhibited in order to make it work. By lowering melanin production, azelaic acid has been demonstrated to be beneficial in reducing hyperpigmentation and evening out skin tone.

Difluoro Cyclohexyloxy Phenol

DeoxyArbutin, also known as difluoro cyclohexyloxy phenol, is a man-made tyrosinase inhibitor that was created as a skin-lightening substance. Arbutin, a naturally occurring tyrosinase inhibitor obtained from plants like bearberry, blueberry, and pear, has been found to be less efficient and unstable than difluoro cyclohexyloxy phenol.

Ellagic Acid

Ellagic acid is a polyphenol that occurs naturally and has been shown to have tyrosinase-inhibiting qualities. By lowering melanin formation, ellagic acid has been demonstrated to be beneficial in reducing hyperpigmentation and evening out skin tone. Additionally, it is a strong antioxidant that has been shown to shield the skin from UV and free radical damage.

Emblica (Emblican)

Tyrosinase has been reported to be inhibited by the natural component emblica, sometimes referred to as emblican or Indian Gooseberry. It is well-known for its anti-inflammatory and antioxidant effects and has been utilised for generations in traditional Indian medicine. It has been discovered to shield the skin from free radical and ultraviolet (UV) radiation harm.

Gentisic Acid

Gentian root and sweet flag are two examples of the many plants that contain the natural substance gentisic acid. Tyrosinase, an enzyme involved in the creation of melanin, a pigment that gives skin, hair, and eyes their colour, has been demonstrated to be inhibited by it. In the cosmetics business, tyrosinase inhibitors like gentisic acid are used to lighten skin and lessen hyperpigmentation.

Hydroquinone

A tyrosinase inhibitor, hydroquinone is a widely used skin lightening treatment. Tyrosinase is an enzyme that helps to make melanin, the pigment that gives skin, hair, and eyes their colour. Hydroquinone helps to lighten skin and minimise hyperpigmentation by blocking tyrosinase, which lowers the formation of melanin.

Hexylresorcinol

Hexylresorcinol is a skin-lightening component used in the cosmetics industry, and it is frequently used in skin care products advertised to lessen the visibility of black spots and enhance the general tone and texture of the skin. More research is required to ascertain the possible advantages and hazards of this compound because its safety and efficiency as a tyrosinase inhibitor have not been thoroughly demonstrated.

Kojic Acid

Kojic acid is a skin-lightening component that is widely utilised in the cosmetics industry. It is frequently used in skin care products that claim to lessen the appearance of black spots and enhance the tone and texture of the skin overall. Although it is thought to be a tyrosinase inhibitor that is generally safe and effective, further research is required to fully understand the possible advantages and hazards of this drug over the long run.

Licorice Extract (Glabridin, Glycyrrhiza glabra)

Tyrosinase activity has been demonstrated to be inhibited by licorice extract, which is made from the plant's root. Tyrosinase plays a role in the synthesis of melanin, the pigment that gives skin, hair, and eyes their colour. Licorice extract helps to lessen melanin formation and lessen the appearance of hyperpigmentation by inhibiting tyrosinase.
In the cosmetics sector, licorice extract is frequently utilised as a natural skin-lightening agent.

Paper Mulberry (Mulberry extract)

In the cosmetics sector, paper mulberry is utilised as a natural skin-lightening agent in place of chemical ones. It is frequently found in products targeted to those with sensitive skin because it is thought to be generally harmless and mild on the skin. More research is required to ascertain the possible advantages and hazards of this compound because its efficacy as a tyrosinase inhibitor has not yet been thoroughly proven.

Resveratrol

Some fruits and plants, including as grapes, blueberries, and peanuts, naturally contain resveratrol, a polyphenol. Some studies have revealed that resveratrol may also reduce the activity of the enzyme tyrosinase, while it is generally known for its antioxidant qualities and possible advantages for cardiovascular health.
Tyrosinase plays a role in the synthesis of melanin, the pigment that gives skin, hair, and eyes their colour. Resveratrol may aid in lowering melanin production and enhancing the appearance of hyperpigmentation by inhibiting tyrosinase.

Resorcinol

Over a century has passed since resorcinol was first utilised in various cosmetic and pharmaceutical goods. Tyrosinase, an enzyme involved in the creation of melanin, the pigment responsible for the colour of skin, hair, and eyes, has been demonstrated to be inhibited by it. Resorcinol aids in lowering melanin formation and enhancing the look of hyperpigmentation by inhibiting tyrosinase.

Best Tyrosinase Inhibitor Products for Treating Hyperpigmentation

Deep within the dermis layer, melanocyte cells produce the pigment known as melanin. Tyrosinase, an enzyme, controls how often and how much melanin is produced by melanocytes. Tyrosinase, an enzyme, aids in the formation of melanin within melanosomes in melanocyte cells, which shields your skin from UV ray damage.

Numerous skincare solutions are available that can aid in minimising the look of hyperpigmentation. Some of the most popular remedies for hyperpigmentation are listed below:

Hyperpigmentation Treatment Products	Prices
Banana Souffle Moisture Cream	₹ 806.00
Coffee Kombucha Probiotic Face Cleanser	₹ 331.00
Turmeric Ginger Revive and Clarify Night Mask	₹ 850.00
Coffee Bean & Green Tea Overnight Mask	₹ 831.00
Power Brightener Vitamin C Serum	₹ 926.00
Ultra Clarifying Acne Treatment Face Oil	₹ 902.00

 

Conclusion

Even while your skin tone may be lovely and even right now, we want to make sure that it stays that way. You can protect your skin and avoid developing hyperpigmentation by using a tyrosinase inhibitor. Hyperpigmentation frequently exists underneath the skin's surface and will become visible later in life. You can stop this hyperpigmentation from developing or showing up at all.
Sunscreen is a crucial component to use in conjunction with your tyrosinase inhibitor for pigmentation, as it is the first line of defence against UV light damage.